Anti-Cancer Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Michelle Prudhomme  
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France

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Anticancer Activity and Anti-inflammatory Studies of 5-Aryl-1,4-benzodiazepine Derivatives

Author(s): Cortez-Maya Sandra, Cortes Cortes Eduardo, Hernandez-Ortega Simon, Ramirez Apan Teresa, Nieto Camacho Antonio, Irina V. Lijanova, Martinez-Garcia Marcos, .

Abstract:

A series of 5-aryl-1,4-benzodiazepines with chloro- or fluoro-substituents in the second ring have been synthesized and their anti-inflammatory, myeloperoxidase and anticancer properties studied. The synthesized compounds showed potential anti-inflammatory and anticancer activities, which were enhanced in the presence of a chloro-substituent in the second ring of the 5-aryl-1,4- benzodiazepine.

Keywords: Anticancer activity, Anti-inflammatory, 1, 4-benzodiazepines, Myeloperoxidase

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Article Details

VOLUME: 12
ISSUE: 6
Year: 2012
Page: [611 - 618]
Pages: 8
DOI: 10.2174/187152012800617713
Price: $58