Anti-Cancer Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Michelle Prudhomme  
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France

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Molecular Imaging of Cancer with Radiolabeled Peptides and PET

Author(s): Amy L. Vavere, Raffaella Rossin.

Abstract:

Radiolabeled peptides hold promise for diagnosis and therapy of cancer as well as for early monitoring of therapy outcomes, patient stratification, etc. This manuscript focuses on the development of peptides labeled with 18F, 64Cu, 68Ga and other positron-emitting radionuclides for PET imaging. The major techniques for radionuclide incorporation are briefly discussed. Then, examples of positronemitting peptides targeting somatostatin receptors, integrins, gastrin-releasing peptide receptors, vasointestinal peptide receptors, melanocortin 1 receptors and others are reviewed.

Keywords: α-MSH, Bombesin, Octreotide analogs, Peptide receptors, PET, RGD, VIP, SOMATOSTATIN, NEUROENDOCRINE TUMORS, INTEGRIN, ANGIOGENESIS

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Article Details

VOLUME: 12
ISSUE: 5
Year: 2012
Page: [462 - 475]
Pages: 14
DOI: 10.2174/187152012800617812
Price: $58