Abstract
Natural products have been a rich source of anticancer compounds. Several anticancer “lead” compounds have been isolated and identified from different natural sources. These lead compounds after proper chemical modifications and bioevaluations afforded potential drugs. In the present article the sources, chemistry and bioactivities of some promising natural anticancer compounds have been discussed. The structure-activity relationship of these natural products and the discovery of useful drugs derived from them have also been highlighted.
Keywords: Natural products, anticancer compounds, sources, bioactivities, mode of action, structure-activity relationship, commercial drugs, Podophyllotoxin, Viblastine, Vincristine, Campotothecin, Taxol, Discodermolide
Mini-Reviews in Organic Chemistry
Title:Natural Products Based Anticancer Agents
Volume: 9 Issue: 2
Author(s): Biswanath Das and Gandham Satyalakshmi
Affiliation:
Keywords: Natural products, anticancer compounds, sources, bioactivities, mode of action, structure-activity relationship, commercial drugs, Podophyllotoxin, Viblastine, Vincristine, Campotothecin, Taxol, Discodermolide
Abstract: Natural products have been a rich source of anticancer compounds. Several anticancer “lead” compounds have been isolated and identified from different natural sources. These lead compounds after proper chemical modifications and bioevaluations afforded potential drugs. In the present article the sources, chemistry and bioactivities of some promising natural anticancer compounds have been discussed. The structure-activity relationship of these natural products and the discovery of useful drugs derived from them have also been highlighted.
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Das Biswanath and Satyalakshmi Gandham, Natural Products Based Anticancer Agents, Mini-Reviews in Organic Chemistry 2012; 9 (2) . https://dx.doi.org/10.2174/157019312800604706
DOI https://dx.doi.org/10.2174/157019312800604706 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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