B Cells: Programmers of CD4 T Cell Responses

Author(s): Tom A. Barr, Mohini Gray, David Gray.

Journal Name: Infectious Disorders - Drug Targets
(Formerly Current Drug Targets - Infectious Disorders)

Volume 12 , Issue 3 , 2012

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Abstract:

B cells are once again gaining prominence as important programmers of CD4 T cell responses. With widespread use of B cell depletion therapy in the clinic, proving effective in treating diseases previously considered T cellmediated, the time is right for a re-appraisal of the B cell. Though typically considered weak, Th2 driving APC, it is now clear that they are necessary for a robust and long-lived CD4 T cell response in many settings. The sphere of B cell influence extends well beyond that of simply antibody production; antigen presentation, cytokine secretion, costimulation and development of lymphoid tissue architecture are all critical aspects of B cell immunobiology, the absence of which has serious impacts for T cell priming and memory. The aim of this review is to look at non-antibody mediated B cell function and to ask how, where and when do B cells influence the CD4 T cell response?

Keywords: B cell, T cell, antigen presentation, TLR, memory, cell responses, antibody production, B cell immunobiology, CD4 T cell response, dendritic cells, protein antigens, gross abnormalities, memory cells, lymphoid organogenesis, amateur

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Article Details

VOLUME: 12
ISSUE: 3
Year: 2012
Page: [222 - 231]
Pages: 10
DOI: 10.2174/187152612800564446
Price: $58

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