The immune system is composed of multiple cell types, which together improve the resistance of the organism
against infections. The unfolding of a successful host response ensuring effective protection against pathogens requires an
appropriate coordination of the different players of the immune system. Innate cells and T cells extensively communicate
during immune reactions, providing multiple opportunities for the mutual coordination of these two defense pathways.
Little is known about the functional interactions between B and innate cells, and it is generally assumed that they influence
each other indirectly through effects on T cells. However, recent studies highlighted important roles for innate cells
in initial presentation of antigen to B cells after immunization, and in long-term maintenance of antibody-producing cells
in bone marrow after resolution of immune responses. Furthermore, it was found that activated B cells could regulate the
activity of innate cells through production of cytokines. Here, we review how direct interactions between innate and B
cells can contribute to orchestration of humoral and cellular immunity.
Keywords: Autoimmunity, B cells, cytokines, humoral immunity, infections, innate cells, neutrophils, immune system, multiple cell, pathogens, Innate cells, antibody-producing cells, immune responses, cellular immunity, immunological memory
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