Abstract
The immune system is composed of multiple cell types, which together improve the resistance of the organism against infections. The unfolding of a successful host response ensuring effective protection against pathogens requires an appropriate coordination of the different players of the immune system. Innate cells and T cells extensively communicate during immune reactions, providing multiple opportunities for the mutual coordination of these two defense pathways. Little is known about the functional interactions between B and innate cells, and it is generally assumed that they influence each other indirectly through effects on T cells. However, recent studies highlighted important roles for innate cells in initial presentation of antigen to B cells after immunization, and in long-term maintenance of antibody-producing cells in bone marrow after resolution of immune responses. Furthermore, it was found that activated B cells could regulate the activity of innate cells through production of cytokines. Here, we review how direct interactions between innate and B cells can contribute to orchestration of humoral and cellular immunity.
Keywords: Autoimmunity, B cells, cytokines, humoral immunity, infections, innate cells, neutrophils, immune system, multiple cell, pathogens, Innate cells, antibody-producing cells, immune responses, cellular immunity, immunological memory
Infectious Disorders - Drug Targets
Title:Functional Interactions Between B Lymphocytes and the Innate Immune System
Volume: 12 Issue: 3
Author(s): Vicky Lampropoulou, Ping Shen, Ellen Hilgenberg, Stefanie Ries, Christian Opitz and Simon Fillatreau
Affiliation:
Keywords: Autoimmunity, B cells, cytokines, humoral immunity, infections, innate cells, neutrophils, immune system, multiple cell, pathogens, Innate cells, antibody-producing cells, immune responses, cellular immunity, immunological memory
Abstract: The immune system is composed of multiple cell types, which together improve the resistance of the organism against infections. The unfolding of a successful host response ensuring effective protection against pathogens requires an appropriate coordination of the different players of the immune system. Innate cells and T cells extensively communicate during immune reactions, providing multiple opportunities for the mutual coordination of these two defense pathways. Little is known about the functional interactions between B and innate cells, and it is generally assumed that they influence each other indirectly through effects on T cells. However, recent studies highlighted important roles for innate cells in initial presentation of antigen to B cells after immunization, and in long-term maintenance of antibody-producing cells in bone marrow after resolution of immune responses. Furthermore, it was found that activated B cells could regulate the activity of innate cells through production of cytokines. Here, we review how direct interactions between innate and B cells can contribute to orchestration of humoral and cellular immunity.
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Cite this article as:
Lampropoulou Vicky, Shen Ping, Hilgenberg Ellen, Ries Stefanie, Opitz Christian and Fillatreau Simon, Functional Interactions Between B Lymphocytes and the Innate Immune System, Infectious Disorders - Drug Targets 2012; 12 (3) . https://dx.doi.org/10.2174/187152612800564374
DOI https://dx.doi.org/10.2174/187152612800564374 |
Print ISSN 1871-5265 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3989 |
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