Experimental Methods and Transport Models for Drug Delivery Across the Blood-Brain Barrier

Author(s): Bingmei M. Fu.

Journal Name: Current Pharmaceutical Biotechnology

Volume 13 , Issue 7 , 2012

Submit Manuscript
Submit Proposal

Abstract:

The blood-brain barrier (BBB) is a dynamic barrier essential for maintaining the micro-environment of the brain. Although the special anatomical features of the BBB determine its protective role for the central nervous system (CNS) from blood-born neurotoxins, however, the BBB extremely limits the therapeutic efficacy of drugs into the CNS, which greatly hinders the treatment of major brain diseases. This review summarized the unique structures of the BBB, described a variety of in vivo and in vitro experimental methods for determining the transport properties of the BBB, e.g., the permeability of the BBB to water, ions, and solutes including nutrients, therapeutic agents and drug carriers, and presented newly developed mathematical models which quantitatively correlate the anatomical structures of the BBB with its barrier functions. Finally, on the basis of the experimental observations and the quantitative models, several strategies for drug delivery through the BBB were proposed.

Keywords: Drug delivery, in vivo and in vitro blood-brain barrier models, paracellular pathway, permeability of the bloodbrain barrier, transcellualr pathway, transport models.

Rights & PermissionsPrintExport Cite as


Article Details

VOLUME: 13
ISSUE: 7
Year: 2012
Page: [1346 - 1359]
Pages: 14
DOI: 10.2174/138920112800624409
Price: $58

Article Metrics

PDF: 17