A Simple and Effective Approach to the Synthesis of Isoquinoline Derivatives Under Solvent-Free Conditions

Author(s): Zinatossadat Hossaini, Faramarz Rostami-Charati, Somayeh Firoziyan, Maryam Sabbaghan, Mohammad A. Khalilzadeh.

Journal Name: Combinatorial Chemistry & High Throughput Screening

Volume 15 , Issue 6 , 2012

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An efficient synthesis of dialkyl pyrrolo[2,1-a]isoquinoline-2,3-dicarboxylates, pyrrolo[1,2-a]quinoline-1,2- dicarboxylates and indolizines is described via one-pot reactions of isoquinoline, quinoline or pyridine and phenacyl bromids with dialkyl acetylenedicarboxylates or diaryloylacetylene under solvent-free conditions at 50oC. The mild reaction conditions and high yields of the products exhibit the good synthetic advantage of these methods.

Keywords: Indolizine, isoquinoline, one-pot reactions, phenacyl bromides, solvent-free, synthesis, multicomponent reactions, NMR specturm, heterocyclic compounds, reactants

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Article Details

Year: 2012
Page: [503 - 508]
Pages: 6
DOI: 10.2174/138620712800563909
Price: $58

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