Second-generation antipsychotics have been growingly implicated in the acute and maintenance treatment for
bipolar affective disorder (BAD). Risperidone long-acting injection (LAI) has been the first second-generation depot
indicated for its maintenance treatment. However, its long-term motor side-effects, especially tardive dyskinesia (TD), has
not been commonly reported or studied. The case reported here a bipolar patient with atypical presentation of TD
involving only the crico-hyoid region of the neck associated with the use of risperidone LAI in adjunct to lithium and
sodium valproate as maintenance therapy.
Keywords: Risperidone long-acting injection, bipolar, maintenance, tardive dyskinesia, crico-hyoid region
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