Endocrine, Metabolic & Immune Disorders-Drug Targets

(Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders)

Emilio Jirillo  
Universitá degli Studi di Bari
Dipartimento di Clinica Medica
Immunologia e Malattie Infettive
Sezione di Microbiologia e Immunologia
Piazza Giulio Cesare-Policlinico


Bone Marrow Microenvironment: A Newly Recognized Target for Diabetes- Induced Cellular Damage

Author(s): Giuseppe Mangialardi, Atsuhiko Oikawa, Carlotta Reni and Paolo Madeddu

Affiliation: Experimental Cardiovascular Medicine, University of Bristol, Bristol Royal Infirmary-level 7, Upper Maudlin St, Bristol BS2 8HW, United Kingdom.


Diabetes mellitus is considered a cardiovascular disease owing to its prevalent association with cardiovascular morbidity and mortality. Cardiovascular events are not only more frequent but also complicated with more severe outcomes in diabetic patients as compared with non-diabetic patients. One mechanism accounting for this difference consists of the impairment of the regenerative cellular machinery, which contributes to tissue healing. Recent evidence indicates the contribution of resident progenitor cells in post-ischemic tissue remodeling. In addition, a wide spectrum of cells from distant sources, including the bone marrow, is attracted and home to the healing tissue. Diabetes affects the process of mobilization and recruitment as well as intrinsic functional properties of bone marrow-derived progenitor cells. This review highlights current evidence for diabetes-induced damage of bone marrow hematopoietic progenitor cells in the endosteal and vascular niches.

Keywords: Bone marrow, diabetes, ischemia, microenvironment, osteoblastic niche, stem cells, vascular niche

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

Page: [159 - 167]
Pages: 9
DOI: 10.2174/187153012800493530