Recent Patents on Anti-Infective Drug Discovery

Dieter Kabelitz  
Institute of Immunology
Universitätsklinikum Schleswig-Holstein
Campus Kiel


Insights into Airway Infections by Enterococci: A Review

Author(s): Vincenzo Savini, Giovanni Gherardi, Daniela Astolfi, Ennio Polilli, Giordano Dicuonzo, Claudio D'Amario, Paolo Fazii, Domenico D'Antonio.


Enterococcus is an uncommon but emerging agent of upper and lower airway diseases, including sinuses, trachea, bronchi, lung and pleural infections. In particular, pneumonia and thoracic empyema may jeopardize the clinical outcome of compromised, hospitalized hosts, as well as affect outpatients. Treatment may feel the effects of inherent and acquired resistances such organisms show to commonly used drugs, with the spread of glycopeptide/vancomycin resistant enterococci (GRE/VRE, respectively) being of serious concern.

With this work, we want to unearth the impact of members of the genus in the ambit of respiratory infections, and to increase the consciousness of their role as resourceful pathogens for human airways. Also, we are revising patents of interest aiming to timely screen GRE and soon provide clinicians with speciation and glycopeptide resistances.

Keywords: vancomycin VRE, Enterococcus, glycopeptides, GRE, lung, pneumonia, teicoplanin, Streptococcus bovis, AIRWAY DISEASE

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Article Details

Year: 2012
Page: [36 - 44]
Pages: 9
DOI: 10.2174/157489112799829774