The Role of Micafungin and Anidulafungin in the Treatment of Systemic Fungal Infections: Applications and Patents for Two Novel Echinocandins
Ludwig Christian G. Hinske, Florian Weis, Jens Heyn, Patricia Hinske and Andres Beiras- Fernandez
Affiliation: Department of Cardiac Surgery; Klinikum Grosshadern Ludwig-Maximilians-University. Munich, Germany.
Keywords: anidulafungin, aspergillosis, candidemia, candidiasis, echinocandins, micafungin, fluconazole, patent, Caspofungin
Fungal infections are becoming an increasing menace in the hospital care setting. Among them, non-albicans Candida species have gained significant attention. Especially in the ICU setting, therapeutic options are limited in many cases by the side-effects of conventional antifungal therapy. Echinocandins are a relatively new class of antifungal agents that promise good effectiveness against Candida and Aspergillus species. Due to their underlying mechanisms of action, they yield good tolerability and few limitations of usage. In the current manuscript we describe the patents of two recently approved echinocandins, micafungin (US approved 2005) and anidulafungin (2006) and provide an overview of the mechanisms, clinical effectiveness and safety of antifungal therapy with these agents.
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