Research Progress on Pathogenesis of Obesity-Induced Insulin Resistance and Its Therapeutic Targets: PPARα/γ

Author(s): Zhigang Qi , Meilin Xie .

Journal Name: Current Signal Transduction Therapy

Volume 7 , Issue 2 , 2012

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Abstract:

Insulin resistance (IR) is defined as a decreased response of peripheral tissues to insulin. It is a common cause of cardiovascular and hepatic diseases, and often precedes the onset of hyperglycemia and predicts the development of type 2 diabetes. Free fatty acids (FFA), inflammation and oxidative stress play key roles in the development and/or progression of IR induced by obesity. Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily; PPAR agonists can improve IR by regulating glucose and lipid metabolisms, and by inhibiting inflammatory and oxidative stress responses. In the article, we will review the pathogenesis of obesity-induced IR, its therapeutic targets: PPARα/γ, and discuss the signal transduction pathways through which these drugs exert therapeutic effects.

Keywords: obesity, insulin resistance, PPARα/γ

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Article Details

VOLUME: 7
ISSUE: 2
Year: 2012
Page: [177 - 184]
Pages: 8
DOI: 10.2174/157436212800376717
Price: $58

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