Current Biotechnology

Pabulo Henrique Rampelotto  
Center of Biotechnology and PPGBCM
Federal University of Rio Grande do Sul
Porto Alegre, RS
Brazil

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Portable Technologies for Self-Monitoring of Coagulation Time: A Review

Author(s): Lynda Metref, Philippe Renaud.

Abstract:

Anti-coagulation treatments are required for medical conditions that become more and more frequent with the ageing of the population in developed countries (atrial fibrillation, deep-venous thrombosis, heart prosthetic valves, etc.). These treatments generally use coumarin derivative (vitamin-K antagonist), whose activity needs to be monitored in order to keep the patient in an appropriate therapeutic range. This measurement can be done in laboratories but can also be performed by the patient himself using portable devices. This paper presents the different technological ways to selfmonitor vitamin-K antagonist treatment by measuring coagulation time. It will focus on portable devices, well suited to be used at home and on device to be manipulated by the patient, thus not requiring an extensive training nor sample treatment.

Keywords: Anti-coagulant, vitamin-K antagonist, coagulation, coagulation time measurement, coumarin, diagnostic, hand-held devices, international normalized ratio, point-of-care, portable devices, prothrombin time, Quick test, self-monitoring, thromboses prevention.

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Article Details

VOLUME: 1
ISSUE: 2
Year: 2012
Page: [155 - 165]
Pages: 11
DOI: 10.2174/2211550111201020155
Price: $58