Abstract
Recent studies indicated that andrographolide was a potential antihyperlipidaemic therapeutic agent. In the paper, the synthesis of a series of andrographolide derivatives was described and their antihyperlipidaemic activities were evaluated in vivo. As compared with TG, TC, HDL-C and LDL-C concentrations, some of the derivatives exhibited better antihyperlipidaemic effects than positive control atromide. Therein, compound 6i, which was the most potent compound, could serve as a new lead for further development of antihyperlipidaemic agents.
Keywords: andrographolide, antihyperlipidaemic activities, derivatives, synthesis, Cholesterol, hyperlipidemia, Green tea, Artichoke, Guggul, plants
Medicinal Chemistry
Title:Synthesis and Preliminary Antihyperlipidaemic Activities Evaluation of Andrographolide Derivatives
Volume: 8 Issue: 2
Author(s): Bin Wang, Chunlei Tang, Yaodan Han, Ruzhou Guo, Hai Qian, Wenlong Huang
Affiliation:
Keywords: andrographolide, antihyperlipidaemic activities, derivatives, synthesis, Cholesterol, hyperlipidemia, Green tea, Artichoke, Guggul, plants
Abstract: Recent studies indicated that andrographolide was a potential antihyperlipidaemic therapeutic agent. In the paper, the synthesis of a series of andrographolide derivatives was described and their antihyperlipidaemic activities were evaluated in vivo. As compared with TG, TC, HDL-C and LDL-C concentrations, some of the derivatives exhibited better antihyperlipidaemic effects than positive control atromide. Therein, compound 6i, which was the most potent compound, could serve as a new lead for further development of antihyperlipidaemic agents.
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Bin Wang, Chunlei Tang, Yaodan Han, Ruzhou Guo, Hai Qian, Wenlong Huang , Synthesis and Preliminary Antihyperlipidaemic Activities Evaluation of Andrographolide Derivatives , Medicinal Chemistry 2012; 8 (2) . https://dx.doi.org/10.2174/157340612800493629
DOI https://dx.doi.org/10.2174/157340612800493629 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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