Synthesis and Study the Analgesic Effects of New Analogues of Ketamine on Female Wistar Rats

Author(s): Abbas Ahmadi, Mohsen Khalili, Ramin Hajikhani, Horiesadat Hosseini, Nasrin Afshin, Babak Nahri-Niknafs.

Journal Name: Medicinal Chemistry

Volume 8 , Issue 2 , 2012

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Abstract:

Ketamine (2-o-chlorophenyl-2-methylaminocyclohexan, CAS 1867-66-9, CI-581, Ketalar, I), a potent derivative of Phencyclidine (1-[1-phenylcyclohexyl] piperidine, CAS 956-90-1, PCP, II), and many of its analogues have shown anesthetic and analgesic effects. In this research, new derivatives of I, (2-[p-methoxybenzylamino]-2-[p-methoxyphenyl] cyclohexanone, ket-OCH3, III), (2-[p-methylbenzylamino]-2-[p-methoxyphenyl] cyclohexanone, ket-CH3, IV) and their intermediates (V-VIIII) were synthesized and the acute and chronic pains of III and IV were evaluated on rats using tail immersion (as a model of acute thermal pain) and formalin (as a model of acute and chronic chemical pain) tests. The results werecompared with ketamine and control (saline) groups. The results indicated that in tail immersion and formalin tests, these new derivatives (III and IV) were usually effective for decreasing pain on rats.

Keywords: Acute and chronic pains, analgesic effects, CAS 1867-66-9, CAS 956-90-1, formalin test, new derivatives of ketamine, tail immersion test, Wistar Rats, binding sites, Melting points, magnesium

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Article Details

VOLUME: 8
ISSUE: 2
Year: 2012
Page: [246 - 251]
Pages: 6
DOI: 10.2174/157340612800493683
Price: $58

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