Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
Email: lddd@benthamscience.org


An Efficient Synthesis, Characterization and Antimicrobial Screening of N-substituted 2-(piperidin-4-yl)-2H-benzo[d] [1, 2, 3] Triazoles

Author(s): Jalapathi Pochampalli, Devender Mandala, Nalla Umapathireddy, Pompu Rajakomuraiah.


A new series N-substituted -2-piperidine-4-yl-2H-benzotriazole (6a-6r) have been synthesized from 4-oxopiperidine- 1-carbaxylic acid tert-butyl ester. The new compounds were screened for their antibacterial activity against Gram positive bacteria (Bacillus subtilis, Bacillus megaterium, Bacillus pumilis, Staphylococcus aurius, Enterobactor aerogens and Streptococcus pyrogens) and Gram negative bacteria (Escherichia coli, Proteus vulgaris, Proteus mirabilis and Klebsiella pneumonia). Compounds 6a, 6b, 6g, 6h, 6k, 6q and 6r showed significant anti bacterial activity. The compounds have also been screened for antifungal activity viz Candida albicance, Fusarium oxysporum, Drechslera halodes,and Colletotrichum falcatum. Compounds 6a, 6b, 6d, 6g, 6h and 6r showed significant antifungal activity.

Keywords: broad spectrum activity, antiseptic, anticoagulant agent, bio active heterocyclic molecules, stock solution, anti-acetyl cholinesterase, antibacterial activities, Staph. Aurius, K2CO3-acetonitrile, Klebsiella pneumonia

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Article Details

Year: 2012
Page: [471 - 478]
Pages: 8
DOI: 10.2174/157018012800389304
Price: $58