Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
Email: lddd@benthamscience.org


An Efficient One Pot Three Component Synthesis of N-(Methylene-4-oxo coumarinyl)anilines; Their Z,E-Isomeric Product Distribution Determination From 1HNMR and their Antibacterial Studies

Author(s): Abdul Rauf, Hamish McNab, Ashfaq Mahmood Qureshi.


The new series of N-(methylene-4-oxo coumarinyl)anilines 1-13 was synthesised and screening of different solvents led to the discovery of high boiling alcohols as the suitable candidate for one pot efficient three component reaction. Particularly in 2-butanol the product was precipitated out in excellent yields without the hassle of purification. The product distribution of Z and E-isomers was established by 1HNMR. These compounds were screened for their in vitro antibacterial activity against Escherichia Coli, Bacillus Subtilis, Shigella flexenari, Staphylococous aureus, Pseudomonas aeruginosa and Salamonella typhi. Standard drug impenium was used as control.

Keywords: coumarins, anti-tumour, chemical shifts, antibacterial, NMR data, micromass analytical machine, d6-DMSO, Z-isomer, E-isomeric product, multicomponent reaction

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Article Details

Year: 2012
Page: [454 - 458]
Pages: 5
DOI: 10.2174/157018012800389377
Price: $58