The Analysis of the Druggable Families Based on Topological Features in the Protein-Protein Interaction Network
Qi Yu, Jing-Fei Huang.
Drug target proteins (DTPs) are mainly distributed in several druggable families. Although proteins in one
druggable family are similar in sequence and structure, not all of them are DTPs. However, the difference between DTPs
and potential target proteins (PTPs) is not yet clear. We explored the topological difference between DTPs and PTPs in
the human protein-protein interaction (PPI) network. Hence we found DTPs exhibited patterns of topological similarity in
the human PPI network. Moreover, we hypothesize that DTPs perturb the network in a controlled manner because their
influences on the PPI network were greater than PTPs’ but less than hubs’. At last, we applied the similarity of topological
features to prioritize PTPs in two largest families. These results demonstrated the potential application of topological
features, which could be helpful to find new DTP candidates.
Keywords: Drug targets, Topological similarity, Protein-protein interaction
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