Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
Email: lddd@benthamscience.org


In Vitro Antioxidant Activity of Some Novel Synthetic Mononuclear Ruthenium (II) Compounds

Author(s): Shyam Sunder Anchuri, Sreekanth Thota, Rajeshwar Yerra, Satyavati Dhulipala.


The present work was aimed that in vitro antioxidant activity of some novel synthetic mononuclear Ruthenium (II) compounds namely, Ru (1, 10-phenanthroline)2(2-nitro Phenyl thiosemicarbazone)Cl2 (compound R1) and Ru (1, 10- phenanthroline)2(2-hydroxy-phenyl thiosemicarbazone)Cl2 (compound R2) using [2, 29-azinobis-(3-ethylbenzothiazoline- 6-sulfonic acid)] (ABTS), Ferric reducing antioxidant power (FRAP), N, N-dimethyl-p-phenylenediamine (DMPD), 1, 1- diphenyl-2-picryl hydrazine (DPPH) and Nitro blue tetrazolium (NBT) assays. The results concluded that both the compounds (R1&R2) exhibited a significant antioxidant activity. But compared to reference standards, R1 was found to be better free radical scavenging activity than R2.

Keywords: Antioxidant, ABTS, DMPD, DPPH, FRAP, NBT, Ruthenium compounds

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Article Details

Year: 2012
Page: [421 - 425]
Pages: 5
DOI: 10.2174/157018012799859927
Price: $58