Synthesis and Anticonvulsant Activity of Some Novel 2-Methyl Imidazole Derivatives
Rahul Mishra, Swastika Ganguly, Kalyan Kumar Sethi, Papiya Mitra Mazumder.
A novel series of ten N-(aryl)-2-(2-methyl-1H-imidazol-1-yl)acetamides (5a-j) were synthesized by reacting 2-
methylimidazole (4) with the corresponding ω- chloroacetanilides (3a-j) in Dimethly Formamide and potassium
carbonate. The compounds have been characterized on the basis of elemental analysis and spectral data. All the
synthesized compounds were screened for their anticonvulsant activity. Among the compounds subjected to
anticonvulsant activity, compounds 5a, 5b, 5d, 5f, 5g, 5h, 5i and 5j, at a dose of 100mg/kg body weight i.p. showed
significant anticonvulsant activity (p<0.01) as they delayed the onset of convulsions. The compounds 5a, 5d, 5h, 5i and 5j
also decreased the duration of seizures significantly (p<0.01 and P<0.05) and the results were comparable to the diazepam
treated group. Compound 5g is the most active molecule as; it increased the onset of convulsion time to nearly two fold
and comparable duration of action to that of diazepam.
Keywords: 2-Methylimidazole, ω- Chloroacetanilides, Acetamides, Anticonvulsant
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