A QSAR Study on Some Thiophene Derivatives Acting as Anti-HCV Agents

Author(s): Jonish Varshney, Anjana Sharma, Satya P. Gupta.

Journal Name: Letters in Drug Design & Discovery

Volume 9 , Issue 4 , 2012

Become EABM
Become Reviewer


A quantitative structure- activity relationship (QSAR) study has been made on a series of thiophene derivatives acting as anti-HCV agents. Significant correlations are found between anti-HCV potencies and some physicochemical parameters. The study reveals that the activity can be controlled by molecular connectivity, Hammett constant, and some indicator variables. Using the correlations obtained, some new prospective compounds having high potency have been predicted.

Keywords: Anti-hepatitis C virus (HCV) agents, Hepatitis C virus inhibitors, QSAR study, Thiophenes

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2012
Page: [389 - 396]
Pages: 8
DOI: 10.2174/157018012799859945
Price: $58

Article Metrics

PDF: 5