A QSAR Study on Some Thiophene Derivatives Acting as Anti-HCV Agents
Jonish Varshney, Anjana Sharma, Satya P. Gupta.
A quantitative structure- activity relationship (QSAR) study has been made on a series of thiophene derivatives
acting as anti-HCV agents. Significant correlations are found between anti-HCV potencies and some physicochemical
parameters. The study reveals that the activity can be controlled by molecular connectivity, Hammett constant, and some
indicator variables. Using the correlations obtained, some new prospective compounds having high potency have been
Keywords: Anti-hepatitis C virus (HCV) agents, Hepatitis C virus inhibitors, QSAR study, Thiophenes
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