Design, Synthesis and Antitumor Activity of Novel Cis-Furoquinoline Derivatives
Jie Li, Shuchen Pei, Yingxi Zhu, Jianbo Wu, Yin Chen, Weiyu Zhang, Yong Wu.
A series of novel cis-furoquinoline derivatives was synthesized and tested for their antitumor activities in vitro
against HepG2 cells, Lu-04 cells and Leu02 cells to evaluate structure-activity relationships. Assay-based antiproliferative
activity study revealed that several compounds had significant effects on cytotoxicity, among which compounds 2f, 2l, 2q
were found to be the most active compounds. Above all, compounds 2f, 2l, 2q would be potential anticancer agents which
deserved further research.
Keywords: Antitumor Activity, Cis-furoquinoline derivatives, c-Kit, Structure-activity relationships (SARs), Synthesis
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