Renin-angiotensin system (RAS) is known to be a regulator of blood pressure, volume homeostasis, and
cardiovascular growth and remodeling, but is still incompletely understood. Tissue RAS plays important roles in
development of target-organ damages in pathological states such as hypertension and diabetes. The pathophysiological
roles of (pro)renin receptor [(P)RR] have been growing concern. (P)RR binds renin and prorenin, with two important
consequences, nonproteolytic activation of prorenin and the intracellular signalings.
In this article, we attempt to elucidate the possible pathophysiological roles of the (P)RR and the therapeutic potential in
primary hypertension, through reviewing studies on animal models of hypertension, transgenic rats overexpressing (P)RR
and genetic analysis in humans.
Keywords: Blood pressure, handle region peptide, intracellular signaling, nonproteolytic activation, polymorphism, reninangiotensin
system, target-organ damage, vacuolar H+- ATPase, phosphorylation
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