Abstract
Vacuolar ATPases (V-ATPases) are large multisubunit complexes that actively transport protons across cellular membranes to acidify intracellular compartments, thereby serving a critical housekeeping function. In addition, VATPases are also expressed on the plasma membrane of cell types such as kidney epithelia and osteoclasts, which require high levels of proton secretion to perform their specialized activities. This multiplicity of function is achieved by the expression of numerous V-ATPase subunit isoforms that are mixed and matched to produce complexes required for each cellular activity. Multiple regulatory mechanisms are necessary to allow coordinated expression of V-ATPase subunit proteins involved in both housekeeping and specialized functions. This review will summarize studies during the last two decades that have revealed transcriptional and post-transcriptional controls that govern expression of V-ATPase subunits. These studies are beginning to elucidate overarching mechanisms that permit coordinated expression of ubiquitous subunits while directing tissue-specific expression of others.
Keywords: Gene expression, microRNAs, mRNA splice variants, mRNA stability, tissue-specific expression, transcription factors, V-ATPases, lectrochemical gradients, reproductive epithelia, HUGO Gene Nomenclature, ne Nomenclature
Current Protein & Peptide Science
Title:Regulation of V-ATPase Expression in Mammalian Cells
Volume: 13 Issue: 2
Author(s): Beth S. Lee
Affiliation:
Keywords: Gene expression, microRNAs, mRNA splice variants, mRNA stability, tissue-specific expression, transcription factors, V-ATPases, lectrochemical gradients, reproductive epithelia, HUGO Gene Nomenclature, ne Nomenclature
Abstract: Vacuolar ATPases (V-ATPases) are large multisubunit complexes that actively transport protons across cellular membranes to acidify intracellular compartments, thereby serving a critical housekeeping function. In addition, VATPases are also expressed on the plasma membrane of cell types such as kidney epithelia and osteoclasts, which require high levels of proton secretion to perform their specialized activities. This multiplicity of function is achieved by the expression of numerous V-ATPase subunit isoforms that are mixed and matched to produce complexes required for each cellular activity. Multiple regulatory mechanisms are necessary to allow coordinated expression of V-ATPase subunit proteins involved in both housekeeping and specialized functions. This review will summarize studies during the last two decades that have revealed transcriptional and post-transcriptional controls that govern expression of V-ATPase subunits. These studies are beginning to elucidate overarching mechanisms that permit coordinated expression of ubiquitous subunits while directing tissue-specific expression of others.
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Cite this article as:
S. Lee Beth, Regulation of V-ATPase Expression in Mammalian Cells, Current Protein & Peptide Science 2012; 13 (2) . https://dx.doi.org/10.2174/138920312800493188
DOI https://dx.doi.org/10.2174/138920312800493188 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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