A Novel Synthesis of Multisubstituted Pyrroles via Trisubstituted Olefins and TosMIC Derivatives

Author(s): Fangli Qiu, Jianwei Wu, Yaohong Zhang, Miao Hu, Feng Yu, Guolin Zhang, Yongping Yu.

Journal Name: Letters in Organic Chemistry

Volume 9 , Issue 4 , 2012

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Abstract:

A novel synthesis of multisubstituted pyrroles was developed where in trisubstituted olefins were reacted with p-toluenesulfonylmethyl isocyanide (TosMIC) derivatives. The entire process is operationally simplistic and utilizes mild reaction conditions. Additionally a possible mechanism is proposed.

Keywords: p-toluenesulfonylmethyl isocyanide(TosMIC), trisubstituted olefins, multisubstituted pyrrole, heterocycles, derivatives

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Article Details

VOLUME: 9
ISSUE: 4
Year: 2012
Page: [305 - 308]
Pages: 4
DOI: 10.2174/157017812800233778
Price: $65

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