Bis-(indolyl)methanes were synthesized by a simple, clean and highly efficient Tween-20 micelle promoted reaction of indole with aldehydes in water by the single step reaction. The absence of electrical double layer in the nonionic surfactant micelles makes them as potential model adsorbent in the interfacial processes. This approach had explored the present synthesis of bis-(indolyl)methanes.
Keywords: Aldehydes, bis-indolylmethanes, green chemistry, indoles, non-ionic surfactants, tween-20, alkaloids, Lewis acids, Ionic liquids, oxalic acid
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