One-Pot Synthesis of Amidoalkyl Naphthols Using POCl3/Na2B4O7 as a Heterogeneous Catalyst

Title:One-Pot Synthesis of Amidoalkyl Naphthols Using POCl3/Na2B4O7 as a Heterogeneous Catalyst

Volume: 9 Issue: 4

Author(s): Hadi Jafari, Hassan Moghanian

Affiliation:

Keywords: 1-Amidoalkyl-2-naphthols, borax, multicomponent reactions, POCl3, HIV, protease inhibitors, Iodine, temperatures, biological screening, benzaldehyde

Abstract: A convenient and efficient procedure for the synthesis of 1-amidoalkyl-2-naphthols by condensation of β- naphthol, aldehydes and amid/urea in the presence of POCl3/ Na2B4O7 is described. This method offers several advantages including low cost and easy availability of the catalyst, environmentally friendly procedure and easy work-up under solvent-free conditions.

Cite this article as:

Hadi Jafari, Hassan Moghanian , One-Pot Synthesis of Amidoalkyl Naphthols Using POCl3/Na2B4O7 as a Heterogeneous Catalyst , Letters in Organic Chemistry 2012; 9 (4) . https://dx.doi.org/10.2174/157017812800233796