Abstract
It is well established that matrix metalloproteinases (MMPs) contribute to the degradation of the extracellular matrix of coronary plaque and contribute to the thinning of the fibrous cap. As a result, the atheromatous plaque becomes unstable and prone to rupture with consequent clinical manifestations including acute coronary syndromes. Moreover, genetic polymorphisms of MMPs have been found to be associated with the concentration of circulating MMPs, and over the past decade, considerable efforts have been devoted to explore the relationships between MMPs polymorphisms and myocardial infarction risk among various populations. However, existing studies have yielded inconsistent results. Some observations have suggested that genetic variation that affects the expression of MMPs may contribute to the occurrence of myocardial infarction, whereas others reported no support for an association of MMPs polymorphisms with myocardial infarction susceptibility. Furthermore, the interpretation of these studies has been complicated by the use of different populations or different control sources. Therefore, further studies are required to evaluate the role of matrix metalloproteinases and especially the associated genetic polymorphisms in cardiovascular disease.
Keywords: Matrix metalloproteinases, gene polymorphisms, atherosclerosis, coronary plaque, coronary artery disease, fibrous cap, acute coronary syndromes, myocardial infarction risk, matrix metalloproteinases, genetic polymorphisms, cardiovascular disease, occlusive thrombus, biologic pathway, risk factors
Current Topics in Medicinal Chemistry
Title:Genetic Variability of Matrix Metalloproteinase Genes in Cardiovascular Disease
Volume: 12 Issue: 10
Author(s): Nikolaos Papageorgiou, Dimitris Tousoulis, George Hatzis, Alexandros Briasoulis, Emmanuel Androulakis, Anastasios Giolis, Gerasimos Siasos, George Latsios, Georgia Vogiatzi, Costas Tentolouris and Christodoulos Stefanadis
Affiliation:
Keywords: Matrix metalloproteinases, gene polymorphisms, atherosclerosis, coronary plaque, coronary artery disease, fibrous cap, acute coronary syndromes, myocardial infarction risk, matrix metalloproteinases, genetic polymorphisms, cardiovascular disease, occlusive thrombus, biologic pathway, risk factors
Abstract: It is well established that matrix metalloproteinases (MMPs) contribute to the degradation of the extracellular matrix of coronary plaque and contribute to the thinning of the fibrous cap. As a result, the atheromatous plaque becomes unstable and prone to rupture with consequent clinical manifestations including acute coronary syndromes. Moreover, genetic polymorphisms of MMPs have been found to be associated with the concentration of circulating MMPs, and over the past decade, considerable efforts have been devoted to explore the relationships between MMPs polymorphisms and myocardial infarction risk among various populations. However, existing studies have yielded inconsistent results. Some observations have suggested that genetic variation that affects the expression of MMPs may contribute to the occurrence of myocardial infarction, whereas others reported no support for an association of MMPs polymorphisms with myocardial infarction susceptibility. Furthermore, the interpretation of these studies has been complicated by the use of different populations or different control sources. Therefore, further studies are required to evaluate the role of matrix metalloproteinases and especially the associated genetic polymorphisms in cardiovascular disease.
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Papageorgiou Nikolaos, Tousoulis Dimitris, Hatzis George, Briasoulis Alexandros, Androulakis Emmanuel, Giolis Anastasios, Siasos Gerasimos, Latsios George, Vogiatzi Georgia, Tentolouris Costas and Stefanadis Christodoulos, Genetic Variability of Matrix Metalloproteinase Genes in Cardiovascular Disease, Current Topics in Medicinal Chemistry 2012; 12 (10) . https://dx.doi.org/10.2174/1568026611208011206
DOI https://dx.doi.org/10.2174/1568026611208011206 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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