Title:A Highly Stereoselective Synthesis of E-(But-1-en-3-yne-1-sulfonyl) hetarenes and Disubstituted 2-Benzothiazolyl Alkynes by Palladium Catalyzed Sonogashira Type Coupling of 2-Chlorovinylsulfones
VOLUME: 9 ISSUE: 4
Author(s): Julija Visnevska, Sergey Belyakov and Edgars Abele
Affiliation:Latvian Institute of Organic Synthesis, 21 Aizkraukles Street, Riga, LV-1006, Latvia.
Keywords:Copper catalysis, E-2-chlorovinylsulfonylhetarenes, E-(but-1-en-3-yne-1-sulfonyl)hetarenes, Palladium catalysis, Sonogashira coupling, dendrimers, triethylamine, salts, atom-numbering, atoms
Abstract:Novel and highly stereoselective route to E-(but-1-en-3-yne-1-sulfonyl)hetarenes by palladium catalyzed Sonogashira type coupling of unstable E-2-chlorovinylsulfonylbenzene and E-2-(2-chlorovinylsulfonyl)pyridine was presented. Usage of potassium phosphate as novel base in Sonogashira reaction was demonstrated. Unusual coupling products in the Sonogashira reaction of E-2-(2-chlorovinylsulfanyl)benzothiazole with different alkynes were obtained.
