Diabetes mellitus (DM) is a leading risk factor for cardiovascular disease that adversely affects multiple vascular
components from early in its course. Current evidence implicates matrix metalloproteinases (MMPs) and their endogenous
inhibitors in diverse pathways associated with the development and progression of diabetic microvascular complications.
In diabetic nephropathy, altered MMPs expression contributes to extracellular matrix deposition and glomerular hypertrophy
that eventually lead to proteinuria and renal insufficiency. In diabetic cardiomyopathy, MMPs participate in the
breakdown of collagen and elastin, myocardial remodelling as well as the vulnerability of the coronary plaque. The development
of diabetic peripheral arterial disease is mediated by the impaired angiogenesis caused by the activity of MMPs.
Experimental data support an integral role of MMPs in cerebral circulation and stroke volume in diabetes. An excess of
MMPs may contribute in poor diabetic wound healing. Future research should further clarify the role of MMPs within the
pathophysiological substrate of diabetes, as well as potential therapeutic options.
Keywords: Diabetes, metalloproteinase, microvascular, atherosclerosis, cardiovascular disease, multiple vascular
components, diabetic microvascular complications, glomerular hypertrophy, diabetic cardiomyopathy, collagen, elastin, coronary plaque, pathophysiological, potential therapeutic
Rights & PermissionsPrintExport