The properties of heparin, a key anticoagulant, are reviewed. The important issues in heparinotherapy, i.e., reaching quick anticoagulant
effect, maintaining therapeutic level of anticoagulation, heparin inhibition and non-invasive heparin formulations have been
reviewed and discussed, with the focus on the role of polymeric substances in the proposed solutions.
Keywords: Heparin, anticoagulation, unfractionated heparin, low molecular weight heparin, heparin reversal, noninvasive delivery, heparinotherapy, heparin inhibition, polymeric substances, glycosaminoglycans (GAGs)
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