Heparin - a Key Drug in the Treatment of the Circulatory Degenerative Diseases: Controlling its Action with Polymers

Author(s): Krzysztof Szczubialka, Kamil Kaminski, Katarzyna Zasada, Anna Karewicz, Maria Nowakowska.

Journal Name:Current Pharmaceutical Design

Volume 18 , Issue 18 , 2012

Abstract:

The properties of heparin, a key anticoagulant, are reviewed. The important issues in heparinotherapy, i.e., reaching quick anticoagulant effect, maintaining therapeutic level of anticoagulation, heparin inhibition and non-invasive heparin formulations have been reviewed and discussed, with the focus on the role of polymeric substances in the proposed solutions.

Keywords: Heparin, anticoagulation, unfractionated heparin, low molecular weight heparin, heparin reversal, noninvasive delivery, heparinotherapy, heparin inhibition, polymeric substances, glycosaminoglycans (GAGs)

Rights & PermissionsPrintExport

Article Details

VOLUME: 18
ISSUE: 18
Year: 2012
Page: [2591 - 2606]
Pages: 16
DOI: 10.2174/138161212800492840