Eight-Year Follow-Up of an Initial Case with NF-κB Decoy Oligodeoxynucleotide Transfection After Coronary Stent Implantation

Author(s): Jun-ichi Suzuki, Daisuke Tezuka, Ryuichi Morishita, Mitsuaki Isobe.

Journal Name: Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Under Re-organization)
(Formerly Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents)

Volume 12 , Issue 1 , 2012


Background: Nuclear factor–kappa B (NF-kB) plays a pivotal role in vascular remodeling after percutaneous coronary intervention (PCI) with a stent implantation.

Methods and Results: This is the first clinical report to demonstrate the effect of NF-kB decoy oligodeoxynucleotide (ODN) on the prevention of restenosis after an eight-year observation period. We revealed that decoy ODN treatment suppressed neointimal formation in comparison to that without ODN transfected stent lesion in the same artery.

Conclusion: We showed the long-term usefulness of NF-kB decoy ODN transfer after PCI.

Keywords: CT, coronary intervention, gene therapy, nuclear factor–kappa B, oligodeoxynucleotide, restenosis, stents

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Article Details

Year: 2012
Page: [40 - 42]
Pages: 3
DOI: 10.2174/187152212799857664

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