Eight-Year Follow-Up of an Initial Case with NF-κB Decoy Oligodeoxynucleotide Transfection After Coronary Stent Implantation

Title:Eight-Year Follow-Up of an Initial Case with NF-κB Decoy Oligodeoxynucleotide Transfection After Coronary Stent Implantation

Volume: 12 Issue: 1

Author(s): Jun-ichi Suzuki, Daisuke Tezuka, Ryuichi Morishita, Mitsuaki Isobe

Affiliation:

Keywords: CT, coronary intervention, gene therapy, nuclear factor–kappa B, oligodeoxynucleotide, restenosis, stents

Abstract: Background: Nuclear factor–kappa B (NF-kB) plays a pivotal role in vascular remodeling after percutaneous coronary intervention (PCI) with a stent implantation.

Methods and Results: This is the first clinical report to demonstrate the effect of NF-kB decoy oligodeoxynucleotide (ODN) on the prevention of restenosis after an eight-year observation period. We revealed that decoy ODN treatment suppressed neointimal formation in comparison to that without ODN transfected stent lesion in the same artery.

Conclusion: We showed the long-term usefulness of NF-kB decoy ODN transfer after PCI.

Cite this article as:

Jun-ichi Suzuki, Daisuke Tezuka, Ryuichi Morishita, Mitsuaki Isobe , Eight-Year Follow-Up of an Initial Case with NF-κB Decoy Oligodeoxynucleotide Transfection After Coronary Stent Implantation , Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) 2012; 12 (1) . https://dx.doi.org/10.2174/187152212799857664