Background: Nuclear factor–kappa B (NF-kB) plays a pivotal role in vascular remodeling after percutaneous
coronary intervention (PCI) with a stent implantation.
Methods and Results: This is the first clinical report to demonstrate the effect of NF-kB decoy oligodeoxynucleotide
(ODN) on the prevention of restenosis after an eight-year observation period. We revealed that decoy ODN treatment
suppressed neointimal formation in comparison to that without ODN transfected stent lesion in the same artery.
Conclusion: We showed the long-term usefulness of NF-kB decoy ODN transfer after PCI.
Keywords: CT, coronary intervention, gene therapy, nuclear factor–kappa B, oligodeoxynucleotide, restenosis, stents
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