Abstract
Cigarette smoking is strongly correlated with many diseases like cancer, cardiovascular disease and macular degeneration. Nicotine, the main active and addictive component of tobacco smoke has recently been shown to enhance angiogenesis in many experimental systems and animal models. The pro-angiogenic activity of nicotine is mediated by nicotinic acetylcholine receptors, particularly the alpha 7 subunit, that are expressed on a variety of non-neuronal cells including those in the vasculature such as endothelial cells and smooth muscle cells. The present review focuses on the role of α7nAChR in mediating the pro-angiogenic effects of nicotine and describes the molecular mechanisms involved in nicotine-induced angiogenesis as well as epithelial to mesenchymal transition. These observations on nicotine function highlight the therapeutic potential of α7nAChR agonists and antagonists for combating angiogenesis related diseases.
Keywords: signaling, arteriogenesis, macular degeneration, cancer, metastasis, smoking, cholinergic system, angiogenesis, neovascularization, EMT
Current Drug Targets
Title:α7 Nicotinic Acetylcholine Receptor Subunit in Angiogenesis and Epithelial to Mesenchymal Transition
Volume: 13 Issue: 5
Author(s): Smitha Pillai and Srikumar Chellappan
Affiliation:
Keywords: signaling, arteriogenesis, macular degeneration, cancer, metastasis, smoking, cholinergic system, angiogenesis, neovascularization, EMT
Abstract: Cigarette smoking is strongly correlated with many diseases like cancer, cardiovascular disease and macular degeneration. Nicotine, the main active and addictive component of tobacco smoke has recently been shown to enhance angiogenesis in many experimental systems and animal models. The pro-angiogenic activity of nicotine is mediated by nicotinic acetylcholine receptors, particularly the alpha 7 subunit, that are expressed on a variety of non-neuronal cells including those in the vasculature such as endothelial cells and smooth muscle cells. The present review focuses on the role of α7nAChR in mediating the pro-angiogenic effects of nicotine and describes the molecular mechanisms involved in nicotine-induced angiogenesis as well as epithelial to mesenchymal transition. These observations on nicotine function highlight the therapeutic potential of α7nAChR agonists and antagonists for combating angiogenesis related diseases.
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Cite this article as:
Smitha Pillai and Srikumar Chellappan , α7 Nicotinic Acetylcholine Receptor Subunit in Angiogenesis and Epithelial to Mesenchymal Transition , Current Drug Targets 2012; 13 (5) . https://dx.doi.org/10.2174/138945012800398847
DOI https://dx.doi.org/10.2174/138945012800398847 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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