α7 nAChR in Airway Respiratory Epithelial Cells

Author(s): Candida Nastrucci, Patrizia Russo.

Journal Name: Current Drug Targets

Volume 13 , Issue 5 , 2012

Submit Manuscript
Submit Proposal

Abstract:

This review examines the role of α7 nAChR in different types of airway epithelial cells of the normal human bronchial tree. In each of these cells α7 nAChR activation elicits a specific effect. The effect is essentially mitogenic, whereas in the airway basal cells are antiproliferative. It is postulated that α7 nAChR may have mitogenic or antiproliferative signals differentially activated in different types of airway cells and under exposure to exogenous stimuli such as nicotine.

Keywords: α7-nAChR, nicotine, HBEC, HSAEC, basal cells, neuroendocrine cell, lung disease, lung function, airway epithelial cell, mitogenic

Rights & PermissionsPrintExport Cite as


Article Details

VOLUME: 13
ISSUE: 5
Year: 2012
Page: [666 - 670]
Pages: 5
DOI: 10.2174/138945012800398865
Price: $58

Article Metrics

PDF: 15