Adipoparacrinology of Atherosclerosis: Evidence Updated

Author(s): George N. Chaldakov, Gorana Rancic, Marco Fiore, Plamen Panayotov, Jerzy Beltowski, Vladmila Bojanic, Luigi Aloe.

Journal Name: Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Under Re-organization)

Volume 12 , Issue 1 , 2012

Abstract:

Recently, the secretory - endocrine, paracrine and autocrine - phenotype of adipose tissue, consisting of adipocytes, stromovascular cells and immune cells, has increasingly been recognized. In humans, adipose tissue is partitioned into two large depots (subcutaneous and visceral) and many small depots associated with heart, blood vessels, major lymph nodes, pancreas, prostate gland, ovaries. Accordingly, two major subfields of adipobiology have emerged, adipoendocrinology (studying the endocrine activity of adipose tissue) and adipoparacrinology (studying the paracrine activity of adipose tissue). Traditional concept of the pathogenesis of atherosclerosis focuses on intimal surface, where endothelial dysfunction expressed by an “inside-out” inflammatory process triggers the formation of atherosclerotic plaque. The present short review highlights evidence for the possible role of dysfunctional paracrine activity of epicardial adipose tissue and of periadventitial adipose tissue in an “outside-in” pathway in the development of coronary and peripheral atherosclerosis, respectively. Such a paradigm may have various therapeutic applications including in coronary artery bypass surgery.

Keywords: Adipobiology, adipokines, atherogenesis, coronary artery, epicardial adipose tissue, neurotrophin, NGF, periadventitial, adipose tissue, therapy

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Article Details

VOLUME: 12
ISSUE: 1
Year: 2012
Page: [2 - 7]
Pages: 6
DOI: 10.2174/187152212799857637

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