Increasing evidence has shown that cytokines have a role in tumor biology. The role of chemokines in tumor biology is important
because these peptides may influence tumor growth, invasion, angiogenesis, and metastasis. In this review, we demonstrated the role
of cytokines (Interleukin-1α, hepatocyte growth factor, Interleukin-8, stromal cell-derived factor-1 and CXC-chemokines/CXCR2 biological
axis) in pancreatic cancer angiogenesis, especially from the standpoint of the interaction between tumor and its microenvironments.
The cytokines are intimately related with cancer angiogenesis. Blocking these cytokines could attenuate pancreatic cancer associated
angiogenesis and further considered as a novel anti-angiogenic target in pancreatic cancer.