Recent studies have demonstrated that the interaction between the cancer and the stroma, play a key role in the development of
pancreatic cancer. The desmoplasia, which consists of fibroblasts, pancreatic stellate cells, lymphatic and vascular endothelial cells, immune
cells, pathologic increased nerves, and the extracellular matrix (ECM), creates a complex tumor microenvironment that promotes
pancreatic cancer development, invasion, metastasis, and resistance to chemotherapy. Thus, the potential approach for targeting the components
of this desmoplastic reaction or the pancreatic tumor microenvironment might represent a novel therapeutic approach to advanced
pancreatic carcinoma. Novel therapies that target on the pancreatic tumor microenvironment should become one of the more effective
treatments for pancreatic cancer.