Therapeutic Potential of Perineural Invasion, Hypoxia and Desmoplasia in Pancreatic Cancer

Author(s): Han Liu, Qingyong Ma, Qinhong Xu, Jianjun Lei, Xuqi Li, Zheng Wang, Erxi Wu.

Journal Name:Current Pharmaceutical Design

Volume 18 , Issue 17 , 2012

Abstract:

Pancreatic cancer is one of the most fatal human malignancies. Though a relatively rare malignancy, it remains one of the deadliest tumors, with an extremely high mortality rate. The prognosis of patients with pancreatic cancer remains poor; only patients with small tumors and complete resection have a chance of a complete cure. Pancreatic cancer responds poorly to conventional therapies, including chemotherapy and irradiation. Tumor-specific targeted therapy is a relatively recent addition to the arsenal of anti-cancer therapies. It is important to find novel targets to distinguish tumor cells from their normal counterparts in therapeutic approaches. In the past few decades, studies have revealed the molecular mechanisms of pancreatic tumorigenesis, growth, invasion and metastasis. The proteins that participate in the pathophysiological processes of pancreatic cancer might be potential targets for therapy. This review describes the main players in perineural invasion, hypoxia and desmoplasia and the molecular mechanisms of these pathophysiological processes.

Keywords: Pancreatic cancer, perineural invasion, hypoxia, desmoplasia, therapeutic targets

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Article Details

VOLUME: 18
ISSUE: 17
Year: 2012
Page: [2395 - 2403]
Pages: 9
DOI: 10.2174/13816128112092395
Price: $58

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