Free Radical Biomedicine: Principles, Clinical Correlations, and Methodologies

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Free radicals and related reactive species, including reactive oxygen and nitrogen species (ROS/RNS) play a critical role in the pathophysiological processes of various human diseases, including ...
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Free Radicals and Related Reactive Species in Cancer

Pp. 217-231 (15)

Y. Robert Li

Abstract

Cancer remains a leading cause of death in the human population worldwide. Both genetic and environmental factors are involved in the development of cancer. Recent work also demonstrates a critical role for reactive oxygen and nitrogen species (ROS/RNS) in multistage carcinogenesis. This chapter examines the oxidative stress mechanism of carcinogenesis as well as antioxidant-based modalities for cancer intervention. The chapter also discusses ROS as a potential tumor killing modality in cancer therapy.

Keywords:

Antioxidant intervention, Cancer, Carcinogens, Initiation, Multistage carcinogenesis, Oxidative stress, Progression, Promotion, Reactive nitrogen species, Reactive oxygen species.

Affiliation:

Virginia Tech Corporate Research Center Blacksburg, Virginia USA