Free Radical Biomedicine: Principles, Clinical Correlations, and Methodologies

Indexed in: Book Citation Index, Science Edition, BIOSIS Previews, Scopus, EBSCO.

Free radicals and related reactive species, including reactive oxygen and nitrogen species (ROS/RNS) play a critical role in the pathophysiological processes of various human diseases, including ...
[view complete introduction]

US $
30

*(Excluding Mailing and Handling)



Free Radicals and Related Reactive Species in Renal Diseases

Pp. 202-216 (15)

Y. Robert Li

Abstract

Kidney diseases are broadly classified into acute kidney injury and chronic kidney disease. They collectively affect approximately 10% of the adult population in the United States and worldwide, and represent a major issue of public health. As our understanding of the pathophysiology of kidney diseases becomes more advanced, various new mechanistically-based therapeutic strategies for treating these diseases have been developed. This chapter summarizes experimental and clinical evidence supporting a causative role of oxidative stress in the pathophysiology of both acute kidney injury and chronic kidney disease. It also discusses the recent development of antioxidant-based intervention of kidney disorders.

Keywords:

Acute kidney injury, Antioxidant intervention, Chronic kidney disease, Nephrotoxicity, Oxidative stress, Reactive nitrogen species, Reactive oxygen species, Renal diseases.

Affiliation:

Virginia Tech Corporate Research Center Blacksburg, Virginia USA