Free Radical Biomedicine: Principles, Clinical Correlations, and Methodologies

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Free radicals and related reactive species, including reactive oxygen and nitrogen species (ROS/RNS) play a critical role in the pathophysiological processes of various human diseases, including ...
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Free Radicals and Related Reactive Species in Neurological Diseases

Pp. 127-152 (26)

Y. Robert Li

Abstract

Due to its high rate of oxygen utilization and richness in lipids containing polyunsaturated fatty acids, the central nervous system is vulnerable to reactive oxygen and nitrogen species (ROS/RNS)- mediated injury. Indeed, increasing evidence shows oxidative stress as an important mechanism underlying various neurological disorders. This chapter summarizes both experimental and clinical data supporting oxidative stress as a critical pathophysiological component of such common neurological diseases as stroke, Parkinson’s disease, and Alzheimer’s disease. The role of oxidative stress in other neurological disorders, including amyotrophic lateral sclerosis, Huntington’s disease, traumatic brain injury, spinal cord injury, and drug/xenobiotic-induced neurotoxicity is also discussed in this chapter.

Keywords:

Alzheimer’s disease, Amyotrophic lateral disease, Antioxidant intervention, Huntington’s disease, Neurological diseases, Neurotoxicity, Oxidative stress, Parkinson’s disease, Reactive nitrogen species, Reactive oxygen species, Spinal cord injury, Stroke, Traumatic brain injury.

Affiliation:

Virginia Tech Corporate Research Center Blacksburg, Virginia USA