MicroRNAs and Cardiovascular Disease

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Micro RNAs (miRNAs) are known to play an important role in gene expression regulation. Owing to their ever-increasing implications in the control of various biological and pathological processes, ...
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miRNAs in Neointimal Lesion Formation

Pp. 84-86 (3)

Zhiguo Wang

Abstract

Several processes including endothelial angiogenesis, vascular neointimal lesion formation, vascular inflammation process, lipoprotein metabolism, and hypertension are critically involved in atherosclerosis. This chapter aims to introduce the role of miRNAs in neointimal formation. Neointimal formation is a common pathological lesion in diverse cardiovascular diseases occurring at sites of subclinical atherosclerosis but are also classical hallmarks of restenosis after stenting, angioplasty, endarterectomy, and arterial transplantation. Neointimal growth is the balance between proliferation and apoptosis of vascular smooth muscle cells. A number of miRNAs, miR-21, miR-143, miR-145, miR-221, and miR-222, have been demonstrated to play important role in neointimal formation. Their corresponding target genes have also been established.

Affiliation:

Department of Medicine, Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada