miRNAs in Neointimal Lesion Formation
Pp. 84-86 (3)
Several processes including endothelial angiogenesis, vascular neointimal lesion formation, vascular
inflammation process, lipoprotein metabolism, and hypertension are critically involved in atherosclerosis. This
chapter aims to introduce the role of miRNAs in neointimal formation. Neointimal formation is a common
pathological lesion in diverse cardiovascular diseases occurring at sites of subclinical atherosclerosis but are also
classical hallmarks of restenosis after stenting, angioplasty, endarterectomy, and arterial transplantation.
Neointimal growth is the balance between proliferation and apoptosis of vascular smooth muscle cells. A number
of miRNAs, miR-21, miR-143, miR-145, miR-221, and miR-222, have been demonstrated to play important role
in neointimal formation. Their corresponding target genes have also been established.
Department of Medicine, Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada