MicroRNAs and Cardiovascular Disease

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Micro RNAs (miRNAs) are known to play an important role in gene expression regulation. Owing to their ever-increasing implications in the control of various biological and pathological processes, ...
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miRNAs in Vascular Angiogenesis

Pp. 76-83 (8)

Zhiguo Wang


Several processes including endothelial angiogenesis, vascular neointimal lesion formation, vascular inflammation process, lipoprotein metabolism, and hypertension are critically involved in antherogenesis or atherosclerosis. This chapter aims to introduce the role of miRNAs in endothelial angiogenesis. Angiogenesis is the growth of new blood vessels from pre-existing vessels. Functional endothelial cells are required for angiogenesis, a process involving proliferation, migration, and maturation of endothelial cells. Several miRNAs have been shown to critically regulate vascular angiogenesis and they can be classified into pro-angiogenic miRNAs and anti-angiogenic miRNAs. Pro-angiogenic miRNAs indentified to date include miR-130a, miR- 17~92 cluster, miR-210, miR-378, miR-7f, miR-27b, and miR-126. The known anti-angiogenic miRNAs include miR-320, miR-221 and miR-222. In addition, the miRNAs that are reportedly involved in tumor vascular biology are also introduced in this chapter.


Department of Medicine, Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada