Human Platelet-Derived Growth Factor Enhances Healing of Ulcers Situated on Non-Foot Sites in Diabetics. A Pilot Study

Author(s): Sanjay Kalra, Bharti Kalra.

Journal Name: Current Drug Therapy

Volume 7 , Issue 1 , 2012

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Abstract:

This prospective, single centre, open –label study assessed the efficacy, efficiency and tolerability of topical recombinant human platelet –derived growth factor (rhPDGF) in the treatment of chronic ulcers at sites other than the foot in 4 patients with diabetes mellitus. RhPDGF gel 0.01% was applied once daily to the target ulcer in these patients. Efficacy was assessed in terms of ulcer size reduction and efficiency as time to complete healing. Safety was assessed in terms of incidence of adverse events. All ulcers healed completely, of which 2 healed within 2 weeks, 1 by 4 weeks, and 1 by 8 weeks.

Keywords: Diabetes, non-foot ulcers, topical rhPDGF, wound healing

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Article Details

VOLUME: 7
ISSUE: 1
Year: 2012
Page: [64 - 66]
Pages: 3
DOI: 10.2174/157488512800389191

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