The use of macrocyclic lactones has become the main stay for the treatment of endo- and ectoparasites in the
cattle industry. Here we review those drugs that are currently approved for use in cattle in the United States. The general
efficacy, tissue distribution and toxicity of each drug formulation are discussed. Included is a discussion regarding the current
status for nematode anthelmintic resistance in cattle populations within the United States. Also provided is a current
summary of ecological effects of macrocyclic lactones residues in manure.
Keywords: Anthelmintic, anthelmintic resistance, bovine, cattle, dung fauna, endectocide, macrocyclic lactones
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