During the degradation of heme by the enzyme heme oxygenase (HO), Carbon monoxide (CO) is generated.
Although it is considered as a non - significant and potentially toxic waste gas of heme catabolism, CO is a key signaling
molecule used to regulate different cardiovascular functions. In this review, we focus the protective roles of CO in
vascular injury/disease, which may be important to explore the overall protective roles of HO-1/CO system in the
pathogenesis of human vascular disease.
Keywords: Carbon monoxide, Heme oxygenase, oxidative stress, hypertension, vascular diseases
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