Role of Carbon Monoxide in Vascular Diseases

Author(s): Ignazio Barbagallo, Giuseppina Marrazzo, Alessandro Frigiola, Agata Zappala, Giovanni Li Volti.

Journal Name: Current Pharmaceutical Biotechnology

Volume 13 , Issue 6 , 2012

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Abstract:

During the degradation of heme by the enzyme heme oxygenase (HO), Carbon monoxide (CO) is generated. Although it is considered as a non - significant and potentially toxic waste gas of heme catabolism, CO is a key signaling molecule used to regulate different cardiovascular functions. In this review, we focus the protective roles of CO in vascular injury/disease, which may be important to explore the overall protective roles of HO-1/CO system in the pathogenesis of human vascular disease.

Keywords: Carbon monoxide, Heme oxygenase, oxidative stress, hypertension, vascular diseases

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Article Details

VOLUME: 13
ISSUE: 6
Year: 2012
Page: [787 - 796]
Pages: 10
DOI: 10.2174/138920112800399086
Price: $58

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