One-Pot Synthesis of Bis(indolyl)methanes: Ruthenium-Catalyzed Reaction of Benzylic Alcoholes and Indoles

Author(s): Shiyong Zhang , Weiyong Fan , Hongen Qu , Chen Xiao , Ning Wang , Lei Shu , Qiaosheng Hu , Liangxian Liu .

Journal Name: Current Organic Chemistry

Volume 16 , Issue 7 , 2012

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RuCl3·3H2O was found to be an effective catalyst for one-pot reactions of benzylic alcoholes with indoles affording the corresponding bis(indolyl)methanes under air atmosphere at room temperature in moderate to excellent yields. It is noteworthy that the RuCl3·3H2O system displayed a preference for the primary versus secondary benzylic group of a benzylic diol in intramolecular competition experiments.

Keywords: Benzylic alcohol, Bis(indolyl)methane, RuCl3·3H2O, Indole.

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Article Details

Year: 2012
Page: [942 - 948]
Pages: 7
DOI: 10.2174/138527212800194827
Price: $58

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